Comparison of the effect of levofloxacin-based three-drug regimen with clarithromycin-based four-drug regimen in the treatment of Helicobacter pylori infection in Birjand: Short Communication

Given the high prevalence of Helicobacter pylori infection in Iran, eradicating it with an effective, low-cost, and easy diet is one of the challenges ahead The aim of this study was designed to compare the effect of "levofloxacin-based regimen “with” clarithromycin-based regimen” in the treatment of Helicobacter pylori. This quasi-experimental study was performed on 161 patients with Helicobacter pylori infection referred to the gastrointestinal clinic of Vali-asr Hospital in Birjand. Patients were randomly divided into two groups A (levofloxacin, pantoprazole and amoxicillin) and B (amoxicillin, pantoprazole, clarithromycin and bismuth sub citrate) and were treated for 14 days. 4 weeks after the end of treatment, the urease breath test was performed to check for eradication In levofloxacin group, 67 patients (91.8%) and in clarithromycin group 55 patients (70.5%), eradication was performed which was statistically significant. (p=0.001). Also, there was no statistically significant difference between the two groups in terms of complications (p=0.3).  The results showed that the levofloxacin-based regimen could be used as an alternative to four clarithromycin-based therapies due to its greater efficacy in eradicating Helicobacter pylori despite the lower number of drugs and similar side effects.